POST-TRANSLATIONAL REGULATION OF OCT4 TRANSCRIPTIONAL ACTIVITY.

Post-translational regulation of Oct4 transcriptional activity.

Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation.It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in multiple heterodimer and homodimer configurations.Very little is known about how formation of these

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